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流式诊断常见B-NHL

发布者: niwanmao | 发布时间: 2021-10-25 12:27| 查看数: 143| 评论数: 0|帖子模式

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淋巴瘤
表型特征
其它诊断信息
CD5+ CD10−

Chronic lymphocytic leukemia
Typical phenotype: CD20 (d), CD22 (d), sIg (d), CD23+, FMC-7−
典型形态学
Mantle cell lymphoma
Variable phenotype not typical for CLL; often CD20 (i), sIg (i), CD23+/−, FMC-7+/−
Cyclin-D1 IHC, t(11;14)/CCND rearrangement
Prolymphocytic leukemia
Variable phenotype, may overlap with CLL and MCL CD20 (+i), sIg (+i), FMC-7+/−, CD5+/−
Large cells prominent nucleoli; exclude blastic MCL
Marginal zone B-cell lymphoma
Variable phenotype, not typical for CLL: CD23−; often CD11c+/−, CD103+/− but not typical for HCL, sometimes cIg only
Growth around and into follicles, may demonstrate plasmacytic differentiation, t(11;18), t(1;14), t(14;18)/MALT-1 rearrangement
Diffuse large B-cell lymphoma
Variable phenotype
Large cells, diffuse growth pattern; consider Richter transformation CLL and MCL
Lymphoplasmacytic lymphoma
Phenotype not typical for CLL, often CD23(-/d), sometimes sIg− but cIg+
Small cells, subset with plasmacytic differentiation Primarily PB and BM
CD5− CD10+

Follicular lymphoma
Usually bcl-2+, CD43−
Some follicular growth, t(14;18)/BCL-2 rearrangement
Diffuse large B-cell lymphoma
Variable phenotype, bcl-2+/−, CD43+/−
Large cells somewhat pleomorphic, diffuse growth
Burkitt lymphoma
Usually bcl-2−,CD10 (+b), CD43+
Uniform intermediate size cells; MYC rearrangement, Ki-67 approximately 100%
Hairy cell leukemia
Typical phenotype: CD20 (b), CD22 (b), CD11c (b), CD25+, CD103+, sIg (i), CD123+
Characteristic morphology; Annexin-A1+
CD5+ CD10+

Follicular lymphoma
Usually bcl-2+, CD43−
Some follicular growth, t(14;18)/BCL-2 rearrangement
Diffuse large B-cell lymphoma
Variable phenotype, bcl-2+/−, CD43+/−
Large cells, diffuse growth pattern
Mantle cell lymphoma
Variable phenotype not typical for CLL; often CD20 (i), sIg (i), CD23+/−, FMC-7+/−
Cyclin-D1 IHC, t(11;14)/CCND rearrangement
Burkitt lymphoma
Usually bcl-2−, CD10 (b), CD43+
Uniform intermediate size cells; MYC rearrangement, Ki-67 approximately 100%
CD5− CD10−

Hairy cell leukemia
Typical pheotype: CD20 (b), CD22 (b), CD11c (b), CD25+, CD103+, sIg (i)
Confirm characteristic morphology
Marginal zone B-cell lymphoma
Often CD11c+/−, CD103+/− but not typical for HCL, sometimes sIg− but cIg+
Growth around and into follicles, maybe plasmacytic t(11;18), t(1;14), t(14;18)/MALT-1 rearrangement
Diffuse large B-cell lymphoma
Variable phenotype
Large cells, diffuse growth pattern
Follicular lymphoma CD10−
Variable phenotype
Some follicular growth, t(14;18)/BCL-2 rearrangement
Mantle cell lymphoma CD5−
Variable phenotype
Cyclin-D1 IHC, t(11;14)/CCND rearrangement


信源:https://ashpublications.org/bloo ... ing-for-hematologic

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