具有广泛浆细胞样分化的边缘带淋巴瘤属于前体浆细胞肿瘤

niwanmao

Cytometry B Clin Cytom. 2011 Mar;80(2):71-82. doi: 10.1002/cyto.b.20571. Epub 2010 Nov 20.
Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells.
Meyerson HJ   , Bailey J   , Miedler J   , Olobatuyi F   .
Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA. hjm2@case.edu

Abstract
Occasional marginal zone lymphomas have extensive plasmacytic differentiation (P-MZL). We present an argument based on our data and previous published observations that P-MZL represent neoplasms of precursor plasma cells. Five P-MZL were analyzed by flow cytometry and the phenotype was compared with conventional MZL, plasma cell myeloma (PCM), reactive plasmacytoses (RP), and normal marrow plasma cells. The clonal cells in four of five P-MZL were CD19+, CD20(dim/⁻), CD38(bright), CD45++, CD56⁻, CD138⁻, and surface light chain(dim/⁻). One case was CD56+, CD138+, and CD19⁻. A separate clonal mature B cell population [CD20+, CD79b+] was not detected in any of these tumors. Hierarchical clustering demonstrated similarity between the neoplastic cells in four of the five P-MZL with plasma cells in RP comprised of precursor plasma cells. Analysis of normal bone marrow plasma cells revealed a CD45++CD38(bright)CD19+CD138⁻/+ precursor plasma cell population similar to the plasma cells in RP and P-MZL and a very small population of mature CD45+/⁻CD38(bright)CD138+CD19⁻ plasma cellsresembling the neoplastic cells in PCM. The findings suggest that P-MZL represents a malignancy of a plasma cell stage of differentiation distinct from the plasma cell stage corresponding to PCM. We propose the term precursor plasma cell neoplasm for these tumors.

全文下载：http://onlinelibrary.wiley.com/doi/10.1002/cyto.b.20571/pdf

专家评述：

P-MZL评述1

P-MZL评述2

huzengwu

good
thing

huzengwu

倪老师，能弄到BD文献评论季刊最后四篇的全文吗？

niwanmao

huzengwu 发表于 2012-07-23 20:05:50

                               
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倪老师，能弄到BD文献评论季刊最后四篇的全文吗？

我会慢慢全部扫描上来的。以后希望大家也能够按照类似方法传文献，一起学习。不一定只有专家能够评论，大家都可以评论自己读的文献的

huzengwu

niwanmao 发表于 2012-7-23 20:43

                               
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我会慢慢全部扫描上来的。以后希望大家也能够按照类似方法传文献，一起学习。不一定只有专家能够评论，大 ...

好耶

niwanmao

<p></p>PDF全文附件见：&nbsp; MZL_Plasma.pdf (2.03 MB, 下载次数: 1, 售价: 2 流星)

2012-7-29 08:37 上传

点击文件名下载附件

，下载需要2颗流星（<a href="http://www.flowcyto.cn/bbs/forum.php?mod=viewthread&amp;tid=1520" target="_blank">为什么？</a>）
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使用流式中文网资料阅读器在线阅读，免流星，内容完全一样（<b>IE8和360浏览器无法显示，建议使用IE9和google chrome浏览器。</b><a href="http://www.flowcyto.cn/bbs/forum.php?mod=viewthread&amp;tid=1527" target="_blank">使用说明</a>）
<br>
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